Moxifloxacin-loaded acrylic intraocular lenses: in vivo performance

Session Details

Session Title: Pseudophakic IOLs: Monofocal

Session Date/Time: Monday 09/10/2017 | 16:30-18:00

Paper Time: 16:54

Venue: Room 2.1

First Author: : H.Filipe PORTUGAL

Co Author(s): :    L. Werner   N. Mamalis   P. Alves   P. Coimbra   M. Gil   J. Guiomar   M. Masson   D. Bozukova

Abstract Details

Purpose:

The main goal of this investigation was to test in vivo the safety and effectiveness of intraocular lenses (IOLs) loaded with moxifloxacin (MFX) in the prophylaxis of post-cataract surgery endophthalmitis. These IOLs would overcome the common constraints associated with the topical antibiotic administration after cataract surgery, such as uncertain patient compliance, drug wastage and side effects.

Setting:

Departamento de Engenharia Química, Universidade de Coimbra, Portugal; PhysIOL, Liège Science Park, Liège, Belgium and University of Iceland, Iceland

Methods:

Clear lens phacoemulsification was bilaterally performed in six 8-week-old New-Zealand rabbits. Rights eyes (RE) were implanted with MFX-loaded hydrophilic acrylic IOLs pre-soaked at 60 ˚C in a MFX solution, autoclaved in the soaking solution and stored for 2 months accordingly to the group previous in vitro studies. Left eyes (LE) were implanted with the unloaded same intraocular lens model. Both eyes received topical dexamethasone while the control eye (LE) also topical MFX. Slit-lamp examination with scoring for inflammatory response was performed and an aqueous humor sample was collected after one week. Post mortem evaluation was undertaken after 4 weeks follow-up.

Results:

Loaded IOLs showed to be stable, non-toxic and did not lead to posterior capsular opacification. Scoring of inflammatory reaction was clinically low. A week after surgery the MFX concentration in the aqueous humor was ~523 ng/mL and thus close to the value found in the eyes treated by conventional topical application (~488 ng/mL). This concentration was twofold higher than the MIC for S. aureus and S. epidermidis. The variability of this concentration in the group of eyes implanted with the soaked IOL was lower than in the control group.

Conclusions:

MFX-loaded IOLs prepared following the methodology previously described and published elsewhere by this group, showed to be safe and as effective as the commercial topically applied MFX eyedrops on rabbits' eyes after clear lens extraction. Safer and more robust results were obtained with the drug loaded IOL than with the topically applied drug.

Financial Disclosure:

is employed by a forNONEprofit company with an interest in the subject of the presentation