Preliminary evidence of the diagnostic ability of the analysis of the sclerocorneal profile for the diagnosis of keratoconus

Session Details

Session Title: Imaging Anterior Segment

Session Date/Time: Sunday 08/10/2017 | 16:00-18:00

Paper Time: 17:04

Venue: Meeting Center Room I

First Author: : A.Martínez-Abad SPAIN

Co Author(s): :    D. Pinero   P. Ruiz-Fortes   R. Perez-Cambroda   R. Soto-Negro   A. Artola        

Abstract Details

Purpose:

To evaluate preliminarily the diagnostic ability for the detection of keratoconus of some parameters provided by a new sclerocorneal profiler system

Setting:

Optometric Clinic of University of Alicante (Alicante, Spain), and Department of Ophthalmology (OFTALMAR), Vithas Medimar International Hospital, Alicante, Spain

Methods:

A total of 29 eyes of 24 patients with ages ranging between 22 and 69 years old were enrolled. Two groups were differentiated: keratoconus (KC) group, including 11 eyes (6 patients), and control or normal (N) group, including 18 eyes (18 patients). All eyes were examined with the Eye Surface Profiler (ESP, Eaglet-Eye BV, Houten, Netherlands). The following parameters were measured and recorded: temporal (Tsag) and nasal (Nsag) sagittal height (12-mm diameter), minimum (MINsag) and maximum (MAXsag) sagittal height, difference between Tsag and Nsag, and best fit sphere for corneal (BFSc), limbus (BFSl) and scleral areas (BFSs).

Results:

Significantly differences were found in KC group compared to N for Tsag (p=0.014) and Nsag (p=0.024). No significant differences among groups were found in MINsag and MAXsag (p=0.44). The difference between Tsag and Nsag was significantly higher in KC group (0.48±0.65 vs. 0.01±0.24 mm, p=0.007). Concerning BFS, only significant differences among groups were found in BFSl, with a steeper value in KC group (5.66±0.55 vs. 6.13±0.49 mm, p=0.019). Receiver Operating Characteristic (ROC) curve analysis revealed that the difference between Tsag and Nsag could predict accurately the presence of KC (area: 0.798, cutoff 0.27 mm, sensitivity/specificity=81.8/88.9%; p=0.008).

Conclusions:

The analysis of sclerocorneal profile may be useful for the detection of keratoconus and could be used as an additional tool in clinical practice. Future studies should confirm these preliminary findings.

Financial Disclosure:

NONE