Posters

Retinal microvascular parameters by OCT and OCT angiography in males with acute coronary syndrome

Poster Details

First Author: I.Matuleviciute LITHUANIA

Co Author(s):    G. Bruzgyte   A. Bobin   D. Zaliuniene              

Abstract Details

Purpose:

Cardiovascular diseases are the leading cause of death worldwide. It is affecting more males than females. We aimed to investigate the relations between retinal microvascular structure in healthy participants and males with acute myocardial infarction using OCT and OCT angiography.

Setting:

This observational study was performed in the Hospital of the Lithuanian University of Health Sciences Kaunas Clinics, Lithuania, between January 2019 and February 2020.

Methods:

Patients with first ST elevation myocardial infarction (MI) were included during five days after MI. Healthy controls with no stenoses in coronary angiography were invited after a scheduled procedure. Exclusion criteria were high refractive error, amblyopia, ocular trauma, intraocular inflammation, vitreoretinal surgery, glaucoma, macular disorders, conditions obscuring the view of the fundus and diabetes. All participants had OCT and OCT angiography of foveal region performed using a swept-source OCT. Retinal and choroidal thickness in ETDRS segments were evaluated. Vascular density (superior, inferior, temporal, nasal, central) and foveal avascular zone (FAZ) parameters evaluated in superficial (SCP) and deep (DCP) capillary plexuses.

Results:

23 healthy (age 56.57; 10.36 (mean; standard deviation)) and 25 MI patients (age 56.28; 8.68) were retained for analysis (p>0.05). Retina was significantly thicker in a healthy group in outer temporal (266.19;13.19 vs. 259.43;9.60, p=0.005) and outer inferior (267.07;12.92 vs. 261.72;10.87, p=0.028) segments and did not differ in any other retinal and choroidal regions (p>0.05). Horizontal parameter of FAZ in DCP (589.67;132.00 vs. 526.44;117.88, p=0.038), vascular density in the inferior SCP (49.82;2.90 vs. 47.97;3.12, p=0.011), nasal DCP (50.25;2.09 vs. 49.21;2.83, p=0.040), inferior DCP (52.90;2.78 vs. 50.97;3.38, p=0.015) regions were bigger in healthy participants, other parameters were insignificant.

Conclusions:

Our data suggests that there could be signs of acute coronary syndrome in retinal microvasculature - decreased retinal thickness in outer temporal and outer inferior regions, horizontal parameter of FAZ in DCP, lower vascular density in inferior SCP, nasal DCP and inferior DCP regions.

Financial Disclosure:

None