Posters

Clinical analysis of contact lens related bacterial keratitis according to culture positivity

Poster Details

First Author: S.Lee SOUTH KOREA

Co Author(s):    C. Cho                    

Abstract Details

Purpose:

The aim of this study was to analyze the clinical aspects of contact lens (CL) related bacterial keratitis (CLRBK) according to culture positivity.

Setting:

Retrospective, Consecutive case series. Department of Ophthalmology, Yeungnam University College of Medicine, South Korea.

Methods:

This was a retrospective review of 123 cases of inpatient with CLRBK who were treated between January 1998 and December 2016. Epidemiology, predisposing factors, clinical characteristics, and treatment outcomes were compared between culture positive (Group CP, 69 eyes, 92 isolates) and culture negative (Group CN, 54 eyes) groups. Microbiological profiles of the CP group were evaluated. Poor outcome was defined as final BCVA less than 0.5, decreased in VA after treatment, or requiring surgical intervention. Risk factors for poor outcome were evaluated in the total cohort and analyzed using multivariate logistic regression.

Results:

Used CL types were daily-wear (54.5%), bandage (23.6%), extended-wear (12.2%), cosmetic-colored (6.5%), and RGP/orthokeratology (3.3%). Culture positivity was 56.1%, and Gram-negative bacteria accounted for 87.0%. Common isolates were Serratia marcescens (29.3%) and Pseudomonas aeruginosa (19.6%). Between the CP and CN group, mean age (25.5:31.0 years, p=0.028), symptom duration (4.6:8.4 days, p=0.039), and extended-wear CL (20.3:1.9%, p=0.002) were significantly different. Epithelial defect size (6.2:8.0 mm2, p=0.435), hypopyon (13.0:5.6%, p=0.165), epithelial healing time (8.8:7.9 days, p=0.300), initial/final BCVA (0.84:0.85 logMAR, p=0.958; 0.22:0.27, p=0.581) were not significantly different. The significant risk factor for poor outcome was hypopyon (OR 4.47, 95% CI=1.30-15.40, p=0.018).

Conclusions:

The CP group was more related to short symptom duration, relatively young age, and extended-wear CLs than the CN group. Treatment outcomes were not significantly different between the CP and CN group. Hypopyon was significant risk factor for poor outcome in CLRBK.

Financial Disclosure:

None