ePoster

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Title:

Rapidly progressing ocular surface squamous neoplasia and topical alpha-2-beta Interferon: does the size matter?

Poster Details

First Author: P. Cid-Bertomeu SPAIN

Co Author(s):    V. Huerva Escanilla   M. Vilatella Ortiz   M. Sancho Romero   M. Dominguez Bernaus           

Abstract Details

Purpose:

To report a case of a large and bilobate vision-threatening ocular surface squamous neoplasia (OSSN) treated conservatively with topical alpha-2-beta interferon (IFN a-2b).

Setting:

Department of Ophthalmology. Arnau de Vilanova University Hospital. University of Lleida. Lleida, Spain.

Methods:

Case Report. Images and follow-up took place between August and December of 2020. Informed consent was obtained from the patient.

Results:

A 58-year-old man presented with an epithelial nodular and bilobed large conjunctival tumour with corneal invasion in his right eye. Rapid progression was determined as he explained a clinical onset of two months. Anterior segment HD-OCT revealed a thickened hyperreflective epithelium and an abrupt transition between normal and abnormal epithelium. Incisional biopsy was performed and histopathologic examination informed a squamous carcinoma with subepithelial infiltration. He was treated with topical IFN a-2b 4 times daily during 12 weeks. Reduction of the size of the tumour was observed during follow-up and total resolution was accomplished with no visible lesions since 6th week.

Conclusions:

Topical IFN a-2b has demonstrated to be and effective treatment of OSSN even in those cases with a large size tumour were surgical management seems to be the only option. Our case aims to highlight the excellent results of this therapy with a large and rapidly progressive squamous conjunctival neoplasia and its good safety profile with no ocular side effects reported.

Financial Disclosure:

None