ePoster

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Title:

Risk factors for repeat Descemet membrane endothelial keratoplasty graft failure

Poster Details

First Author: E. Cohen CANADA

Co Author(s):    M. Mimouni   N. Sorkin   T. Trinh   G. Santaella   C. Chan   D. Rootman     

Abstract Details

Purpose:

To evaluate re-Descemet Membrane Endothelial Keratoplasty (DMEK) success rates and to identify risk factors for re-DMEK failure.

Setting:

institutional, retrospective

Methods:

A chart review was performed, including all eyes with primary DMEK failure who underwent re-DMEK between 2013 to 2019 at the Toronto Western Hospital and the Kensington Eye Institute (Toronto, Ontario, Canada) and had at least 6 months of follow-up. Main outcome measure: predicting factors for re-DMEK outcome

Results:

Forty eyes met inclusion criteria, etiologies for primary DMEK were Fuchs endothelial dystrophy (32.5%), pseudophakic bullous keratopathy (35%), prior failed graft (27.5%), other indications (5%). 55 percent were categorized as having complicated anterior segment including 11 eyes with previous glaucoma surgery, 7 eyes post PKP, 4 eyes post DSAEK, 3 eyes peripheral anterior synechia, 3 eyes previous vitrectomy, 2 eyes aphakia and 3 eyes other indications. Re-DMEK failure was documented in 12 eyes (30%). The risk factor for re-DMEK failure was the presence of complicated anterior segment (p=0.01, OR=17.0 (95% CI 1.92-150.85)), with 50% re-DMEK failure rate in this subgroup

Conclusions:

re-DMEK is a viable option for cases of primary DMEK failure, especially for eyes with fuchs endothelial dystrophy as indication for primary DMEK without other ocular morbidities, however, eyes categorized with complicated anterior segment, had high re-DMEK failure rates.

Financial Disclosure:

None