Free Papers
Evaluation of the effect of long-term topical latanoprost eye drop treatment on Meibomian gland function and morphology with non-contact Meibography
Free Paper Details
First Author: E.Cetinkaya TURKEY
Co Author(s): M. Kalayci K. Yigit
Abstract Details
Purpose:
To evaluate the morphology and function of Meibomian glands in the lower and upper eyelids with Sirius Meibography in patients who have been using topical latanoprost eye drops for at least 3 years due to glaucoma disease.
Setting:
ANTALYA TRANİNG and RESEARCH HOSPİTAL
Methods:
This single-center, prospective, case-control study included 21 patients and 21 age-matched healthy volunteers. The patient group used only latanoprost eye drops as anti-glaucomatous therapy. Comprehensive eye examination, Schirmer 1 test, tear film breakup time (t-BUT) measurements and fluorescein 2% staining of ocular surface (scored according to Oxford scale) were performed. Symptoms of the subjects were assessed with ocular surface disease index (OSDI) questionnaire. In addition, both eyes upper and lower eyelid Meibomian glands of the participants were evaluated with the Phoenix-Meibography imaging module in combination with Sirius corneal topography.
Results:
The mean meiboscores of the upper and lower eyelids were significantly higher in those using latanoprost than healthy volunteers (p <0.05). The mean BUT and Schirmer 1 test was significantly lower in those using latanoprost. However, OSDI score, Oxford scale and lid margin abnormality score were significantly higher in patients using latanoprost (p <0.05). Percentage of partial / complete gland loss, and percentage of thickened and curled Meibomian gland in upper / lower lids were statistically significantly higher in latanoprost eye drops users (p <0.05).
Conclusions:
Long-term use of latanoprost eye drops was associated with alterations in meibomian gland morphology and function. Sirius Meibography seems useful in the diagnosis and follow-up of Meibomian gland dysfunction.
Financial Disclosure:
-
