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The effect of cone localization on higher order aberrations after corneal cross-linking for keratoconus

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First Author: G.Yalçınkaya TURKEY

Co Author(s):    G. Yalçınkaya   N. Kandemir Beşek   A. Kırgız              

Abstract Details

Purpose:

To evaluate the effects of corneal collagen cross-linking (CXL) on topographic parameters, visual acuity, and corneal high-order aberrations according to preoperative cone location in keratoconus.

Setting:

University of Health Sciences, Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey

Methods:

In this retrospective study, the patients with keratoconus who underwent CXL between March 2016 and February 2019 were evaluated. Patients with a history of corneal surgery, corneal hydrops, corneal scar tissue, delayed epithelial healing, and corneal thickness ˂400μm were excluded. According to the preoperative cone location, eyes were divided into two groups: The K max in the central 3mm optical zone (group 1) and the central 3mm to 5mm optical zone (group 2). Preoperative and postoperative 24 months best-corrected visual acuity (BCVA), intraocular pressure, K max, symmetry index front, corneal thickness, and high order aberrations were recorded.

Results:

The study included 67 eyes of 67 patients with keratoconus, of which 39 in group 1, and 28 in group 2. There were statistically significant differences between the groups in terms of preoperative BCVA values (p=0.04). There was no significant difference between the preoperative and postoperative mean K max between the two groups (p=0.08). The mean difference of corneal thickness between preoperative and postoperative was significantly lower in group 2 than group 1 (p = 0.03). Preoperative and postoperative mean spherical aberration was significantly higher in group 1 than group 2 (p = 0.001 and p = 0.005, respectively).

Conclusions:

Preoperative cone location in keratoconus may affect CXL outcomes. At the end of 24 months, it was found that CXL had similar efficacy on visual acuity and keratometry parameters in the central and paracentral cone groups, and, the recovery in terms of a spherical aberration among high-order aberrations after CXL in the central cone group was better than the paracentral cone group.

Financial Disclosure:

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