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Are Corneal Biomechanical Features Helpful in Guiding Concomitant Systemic Disease Diagnosis in Patients with Angioid Streaks?

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First Author: O.Sonmez TURKEY

Co Author(s):    O. Sonmez   M. Kocamaz   N. Alagoz              

Abstract Details

Purpose:

Angioid streaks may occur in isolation named idiopathic or as an ocular manifestation of several systemic diseases. We aimed to investigate the corneal biomechanical properties in patients with angioid streaks in relation to their etiological background.

Setting:

University of Health Sciences, Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey

Methods:

Patients diagnosed to have angioid streaks on fundoscopic examination in our clinic were included in this cross-sectional study. Patients whose skin biopsy was compatible with pseudoxanthoma elasticum (PXE) were classified as Group 1, and idiopathic patients as Group 2. An age-matched control group of healthy individuals comprised the third group (Group 3). Corneal biomechanical properties of the patients were evaluated with the Ocular Response Analyzer (ORA) and ultrasonographic pachymetry. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), corneal-compansated intraocular pressure (IOPcc) and ultrasonographic pachymetry values of the three groups were analysed and compared for differences.

Results:

The study involved 61 eyes of 61 patients of which 17 eyes were included in Group 1, 14 eyes in Group 2 and 30 eyes in Group 3. The mean CRF and IOPg of PXE positive patients were found to be significantly higher than that of the patients in Group 2 (p=0.006, p=0.017 respectively) and Group 3 (p=0.007, p=0.001), while the the mean values for CH, CRF, IOPg and IOPcc were found to be similar between idiopathic patients and control group (p<0.05, for all).

Conclusions:

High CRF value in corneal biomechanical measurements in patients with angioid streaks may be related to pseudoxanthoma elasticum disease.

Financial Disclosure:

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