 
First Author: M.Karageorgieva BULGARIA
Co Author(s): R. Hristova
Purpose: 
To study the frequency of risk factors for progression among glaucoma patients treated in the clinic 
Setting: 
: Queen Joanna University Hospital - Ophthalmology Department - Sofia, Bulgaria 
Methods: 
 The research is retrospective and includes 466 patients with glaucoma and ocular hypertension treated in the clinic from 01.01.2010 to 01.07.2011. 
    All patients have been obligatory fully examined as    follows: visual acuity with correction, biomicroscopy, gonioscopy of iridocorneal angle, IOP fluctuation, fundoscopy, perimetry, CCT. The main risk factors that may influence the progression of glaucoma have been examined. 
Results: 
 Risk Factors are examined among 466 patients with glaucoma (100%)         
                                                                                           
1.	Age -                                                                    412 patients                                (88.4%).
2.	High IOP -                                                           446 patients                               (100%).
3.	Myopia -                                                               75 patients                                   (16%).
4.	Family history -                                                   20 patients                                  (4.3%).
5.	CCT (measured in 100 patients) -                    65 patients                                  (65%).
6.	Arterial hypertension -                                    230 patients                                 (49.4%).
7.	Vascular pathology -                                        101 patients                                  (21.7%).
8.	PEX -                                                                      92 patients                                (19.7%.)
9.	Diabetes ?  -                                                        35 patients                                    (7.5%).
10.	Others*                                                              92 patients                                  (19.7%).
*Over 30 other diseases are risk factors and are grouped as “others”: Endocrine (without diabetes) – most commonly Hashimoto thyroiditis; Autoimmune – RA; Bone/tendon degenerations – arthroses.
    Distribution by gender:  Women: 330 patients (70.8%); Men:  136 patients (29.2%).
    Distribution by age:
0-18 years:  1 patient (0.2); 19-45years: 46 patients (9.9%); 46-65 years:  54patients (11.6%); Over 66 years:  365 patients (78.3 %). 
Conclusions: 
 According to the results of our study the frequency of glaucoma is higher in women and in the age over 45.
There is a big variety of risk factors as trigger mechanism for glaucoma as is the risk of progression.
The most common risk factors are: high IOP, age, CCT, arterial hypertension, PEX, vascular pathology, etc.
A fact of interest is the frequency of autoimmune diseases, associated with glaucoma, which supports the presence of similar mechanisms for  development of these two pathologies.
There is a hypothetic  connection between glaucoma and Hashimoto’s disease.
Some  bone tendon degenerative diseases also show association with the development of glaucoma. 
Financial Disclosure: 
 None