Analysis of macular ganglionic cell complex and retinal nerve fiber layer in primary open angle glaucoma, ocular hypertension and normal population

Poster Details

First Author: N.Barua INDIA

Co Author(s):    C. Sitaraman   S. Goel   S. Thakur   S. Mukherjee   M. Singh   H. Parashar

Abstract Details

Purpose:

Ganglion cell complex (GCC) consisting of 3 layers Ganglion cell layer, nerve fiber layer and inner plexiform layer, become thinner as the ganglion cells die from the glaucomatous process. OCT a reliable, reproducible preperimetric tool helps in diagnosing disease earlier than detectable functional loss. We aimed at analyzing structural changes and their correlation with visual field sensitivity (MD) among Primary open angle glaucoma, Ocular hypertension as compared to normal population. We also intended to compare the predictive value of each of the parameter in each group.

Setting:

: Anand Hospital and Eye Centre, Jaipur

Methods:

Single day cross sectional study. 40 patients were enrolled in each group after consent. Patents’ have undergone applation tonometry, pachymetry by OCT (RT-Optovue), gonioscopy, visual field analysis (HFA-2) and OCT (RT-optovue) were done . In OCT 5 parameters of macular GCC : average, superior, inferior, Focal and Global loss of volume and 3 parameters of retinal nerve fiber layer : average, superior, inferior were recorded. Data analysed with SPSS, ANOVA, T test, pearson’s correlation. Patients were divided into 5 groups: POAG/CONTROL, POAG/OHT, OHT/CONTROL, EARLY POAG/CONTROL, EARLY POAG/OHT and ROC was calculated for each parameter in each subgroup

Results:

All group were age and sex matched. POAG patients had a statistically significant thinner GCC, RNFL thickness compared to OHT and normal patients. (T test, p is 0.00, po.5) . There is strong negative correlation between all parameters except FLV and GLV is positively correlated. In POAG/ normal group AUC is .820 for GCC average, .774 for GCC superior, .827 for GCC inferior, .796 for FLV, .791 for GLV, .821 for RNFL average, .763 for RNFL superior, .816 for RNFL inferior. In POAG/OHT group AUC were .820, .776, .825, .669, .743, .744, .671, .738 respectively. In OHT/normal none of the parameters had statistically significant AUC values. In early POAG/normal and POAG/OHT population only Inferior GCC had statistically significant AUC value (.715).

Conclusions:

GCC and RNFL thickness become thinner as the disease progresses, Focal and global loss of volume increases (P
Financial Disclosure:

None

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