Comparative study between topical gatifloxacin 0.5% and moxifloxacin 0.5% as a prophylactic measure before intraocular surgery

Session Details

Session Title: Cataract
Session Date/Time: Saturday 10/02/2018 | 08:30-11:00
Paper Time: 09:48
Venue: Blue Hall

First Author: M.Nasif Saadalla EGYPT
Co Author(s): A. Abdel-Meguid  A. Gabr  M. Mostafa Said  T. Elmenofy        

Abstract Details

Purpose:

To compare equal concentrations (0.5%) of moxifloxacin and gatifloxacin ophthalmic solutions as regards conjunctival bacterial reduction as well as anterior chamber penetration.

Setting:

ophthalmology department, faculty of medicine , Fayoum university hospital.

Methods:

In the present study, 100 patients were included and divided into two groups. Group A, received moxifloxacin hydrochloride ophthalmic solution and group B: received gatifloxacin 0.5% ophthalmic solution. The patients were instructed to use their antibiotic drops 4 times a day for 3 days before surgery and 5 times with 30 minutes intervals on the day of surgery. Two conjunctival swabs were obtained; one prior to instillation of antibiotic and the second 30 minutes after instillation of the last antibiotic drop. Specimens were sent for culture and susceptibility testing. At the time of surgery 0.1 ml of aqueous fluid was aspired and aqueous concentration of fluoroquinolones was identified using reverse-phase high-pressure liquid chromatography assay technique.

Results:

The commonest flora isolated were Coagulase negative Staphyloccus (32.9%) followed by Staphylococcus aureus (24.8%), Corynebacterium diphtheria (19.1%). Moxifloxacin aqueous concentration was higher compared to gatifloxacin (1.75 ± 0.98 SD and 0.75 ± 0.22 SD, respectively). This 2.3 folds difference in aqueous humor antibiotic concentrations was statistically significant (P = <0.001). There was significant difference between the means of conjunctival colony forming unit after antibiotic administration in both study groups (2.17 ± 1.54 SD in moxifloxacin group and 1.56 ± 1.09 SD in gatifloxacin group).

Conclusions:

Moxifloxacin 0.5% was found to penetrate anterior chamber more than gatifloxacin 0.5% however, gatifloxacin 0.5% eye drops was able to reduce conjunctival bacterial load more exhibiting superior retentive more than penetrating ability of that fourth generation fluoroquinolones.

Financial Disclosure:

None